Article Contents ::
Details About Generic Salt :: Flutamide
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| FLUTAMIDE |
| ANTI-ANDROGEN | ANTI-NEOPLASTIC |
| PK: A: Rapid & complete E: Urine |
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Indications & Dose: METASTATIC PROSTATE CANCER Combination therapy PO Adult 250mg q8h with luteinizing hormone releasing hormone analog, total dose 750mg/day |
| Contra: Severe hepatic impairment
Precautions: CVD, mild-to-moderate hepatic impairment, avoid excessive alcohol consumption ADR: Serious: HTN, edema, blurred vision, hemolytic anemia, SLE-like syndrome, lymphoedema, hepatic injury, Others: rash, dizziness, Gynaecomastia, nausea, vomiting, diarrhea, increased appetite, insomnia, tiredness, decreased libido, gastric & chest pain DDI: Serious Warfarin increased anticoagulant effect, Theophylline increases drug level Monitor: LFTs |