Details About Generic Salt ::  Cefoxiti

Main Medicine Class:: Antibiotic,cephalosporin   

(seff-OX-ih-tin SO-dee-uhm)

Mefoxin

Class: Antibiotic/cephalosporin

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of infections of lower respiratory tract, urinary tract, skin and skin structures, bone and joint; treatment of intraabdominal infections, gynecological infections and septicemia due to susceptible microorganisms; perioperative prophylaxis. Many infections caused by gram-negative bacteria resistant to some cephalosporins and penicillins respond to cefoxitin.

Drug Dose ::

 Route/Dosage

Infection

ADULTS: IV/IM 1–2 g q 6–8 hr. CHILDREN ³ 3 MO: IV/IM 80–160 mg/kg/day in divided doses q 4–6 hr (maximum 12 g/day).

Surgical Prophylaxis

ADULTS: IV/IM 2 g just prior to surgery then 2 g q 6 hr for 24 hr. CHILDREN ³ 3 MO: IV/IM 30–40 mg/kg just prior to surgery then 30–40 mg/kg q 6 hr for 24 hr.

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: In children ³ 3 mo, high doses of cefoxitin have been associated with increased incidence of eosinophilia and elevated AST. Hypersensitivity: Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients due to possible crossreactivity. Pseudomembranous colitis: Should be considered in patients in whom diarrhea develops. Renal impairment: Use drug with caution. Dosage adjustment based on renal function may be required. Superinfection: May result in bacterial or fungal overgrowth of non-susceptible microorganisms.

Drug Side Effects ::

 Adverse Reactions

CV: Hypotension. GI: Nausea; vomiting; diarrhea; colitis, including pseudomembranous colitis. GU: Renal dysfunction; elevated renal function tests; pyuria; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy. HEMA: Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; hemolytic anemia; aplastic anemia; hemorrhage. HEPA: Hepatic dysfunction; jaundice; abnormal liver function test results. OTHER: Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness–like reactions (eg, skin rashes, polyarthritis; arthralgia, fever); phlebitis, thrombophlebitis and pain at injection site.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Aminoglycosides: May increase risk of nephrotoxicity. Probenecid: Inhibition of renal excretion of cefoxitin. INCOMPATIBILITIES: Do not add aminoglycosides to cefoxitin solutions because inactivation of both drugs may result; administer at separate sites if concurrent therapy is indicated.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note allergy to cephalosporins and penicillins.
• Obtain specimens for culture and sensitivity before beginning therapy and periodically during treatment.
• Monitor renal function carefully during treatment.
• Monitor for signs of infection, especially fever, and for positive response to antibiotic therapy.
• Monitor for coagulation abnormalities. Elevated prothrombin time or abnormal platelet count may occur. If bleeding occurs and PT is prolonged, vitamin K may be indicated.
• Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal spasm). Have resuscitation equipment available.
• Assess for signs of superinfection, such as vaginitis or stomatitis.
• Assess for diarrhea with blood or pus, which may be symptom of pseudomembranous colitis. Symptoms may occur after antibiotic treatment.
• Monitor IV site for vein irritation, infiltration, infection and thrombophlebitis.

Drug Storage/Management ::

 Administration/Storage

• For IM administration reconstitute each gram with 2 ml of Sterile Water for Injection or 2 ml of 0.5% lidocaine without epinephrine to minimize discomfort. Inject deeply into large muscle (eg, gluteus or lateral thigh).
• For IV use, reconstitute each gram with 10 ml of Sterile Water for Injection. Administer slowly over 3–5 min. Reconstituted drug may be diluted in 50–100 ml of 0.9% Sodium Chloride or D5W and infused over 30 min.
• Change IV sites every 48–72 hr.
• Solutions are stable for 24 hr at room temperature and for 1 wk if refrigerated.
• May freeze medication. Thaw at room temperature. After thawing, discard unused portion. Do not refreeze. Do not administer if solution is cloudy or precipitate is present.

Drug Notes ::

 Patient/Family Education

• Instruct patient to check body temperature daily. If fever persists for more than a few days or if high fever (> 102°F) or shaking chills are noted, physician should be notified immediately.
• Advise patient to maintain normal fluid intake while using this medication.
• Advise diabetic patient to use enzyme-based tests (eg, Clinistix, Testape) for monitoring urine glucose because drug may give false results with other tests.
• Warn patient to report these symptoms to physician: nausea, vomiting, diarrhea, skin rash, hives, sore throat, bruising, bleeding, muscle or joint pain.
• Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
• Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home.
• Instruct patient to seek emergency care if he or she experiences wheezing or difficulty breathing.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.