The Brand Name NIACIN Has Generic Salt :: Amikacin 

NIACIN  Is From Company Nac Int. Priced :: Rs. 17.00/35.00

NIACIN have Amikacin is comes under Sub class Aminoglycosides of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Aminoglycosides 

Indications for Drugs ::

Tuberculosis, Complicated and recurrent urinary tract infections, Severe Gram-negative infections, Non-tubercular mycobacterial infections, Bacterial septicemia, Infections of the respiratory tract, Bones and joints, Central nervous system and skin and soft tissue, Intra-abdominal infections, Burns, Postoperative infections, Meningitis, Peritonitis, Neonatal sepsis

Drug Dose ::

Parenteral Uncomplicated urinary tract infections Adult: 250 mg bid, given via IM, IV inj over 2-3 minutes or as IV infusion. Severe Gram-negative infections resistant to gentamicin and tobramycin Adult: 15 mg/kg daily in equally divided doses injected every 8 or 12 hr for 7-10 days. Max: Up to 500 mg every 8 hr in life-threatening infections. Max cumulative dose: 15 g. Doses may be given via IM, slow IV inj over 2-3 minutes or IV infusion. Child: 15 mg/kg daily in equally divided doses injected every 8 or 12 hr for 7-10 days. Neonates: 10 mg/kg daily in 2 divided doses. Impaired renal function: In patient with impaired renal function the daily dose should be reduced and/or the intervals between doses increased to avoid accumulation of the drug. Simple doses schedule for renal impairment is given below: Renal function Dosage schedule Mild impairment 500 mg every 18 hours Moderate impairment 500 mg every 24 hours Severe impairment 250 mg every 24 hours.

Contraindication ::

Pregnancy, perforated ear drum, myasthenia gravis, hypersensitivity.

Drug Precautions ::

Renal impairment; vertigo, tinnitus. Discontinue if signs of ototoxicity, neurotoxicity or hypersensitivity occurs; lactation. Safety has not been established for treatment period >14 days. Monitor renal function before and during treatment.

Drug Side Effects ::

Tinnitus, vertigo; ataxia and overt deafness. Potentially Fatal: Ototoxicity, nephrotoxicity, neuromuscular blockade.

Pregnancy category ::

4

Drug Mode of Action ::  

Amikacin binds to 30S ribosomal subunits of susceptible bacteria, thus inhibiting its protein synthesis.

Drug Interactions ::

Amphotericin B may lead to increased nephrotoxicity and reduced clearance of amikacin when used together. Potentially Fatal: Increased ototoxic or nephrotoxic effects with other nephrotoxic or ototoxic drugs. Enhanced neuromuscular blockade with neuromuscular blocking drugs. Increased risk of ototoxicity with potent diuretics.