Abacavir

Details About Generic Salt ::  Abacavir 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Anti Retrovirals (Drugs for HIV)

13N. ANTI-RETROVIRALS (DRUGS FOR HIV) in 13. ANTI-INFECTIVES
ABACAVIR
REVERSE TRANSCRIPTASE INHIBITOR (NUCLEOSIDE) | ANTI-RETROVIRAL
PK: A: Rapid D: 0.86 L/kg (Vd) M: Liver E: Urine & feces

Indications & Dose: HIV-1 INFECT PO Adult 300mg BID/600mg OD Child 3 month-16 yr: 8mg/kg BID, max 600mg/day | NON-OCCUPATIONAL EXPOSURE TO HIV INFECTION Combination therapy Adult 300mg BID/600mg OD with other two antiretrovirals

Contra: moderate-to-severe hepatic impairment, hypersensitivity, lactic acidosis, children

Precautions: impaired renal function, bone marrow suppression, risk factors for hepatic disease, elderly

ADR: Serious: hypersensitivity, anaphylaxis, erythema multiforme, SJS, TEN, pancreatitis, lactic acidosis, severe hepatomegaly & steatosis, Others: GI disturbances, headache, weakness, insomnia

DDI: Serious Phenytoin/Phenobarbital decreases drug concentration

Diet: With/without food

Monitor: CBC, LFTs, TGs, serum amylase & creatine kinase, signs & symptoms of hypersensitivity

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