Acarbose

Details About Generic Salt ::  Acarbose 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Insulin , Anti Diabetic drugs

8D. INSULIN & ANTI-DIABETIC DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
ACARBOSE
A-GLUCOSIDASE INHIBITOR | ANTI-DIABETIC
PK: A: Poor D: 0.32 L/kg (IV) M: GIT E: Urine % Feces

Indications & Dose: TYPE 2 DIABETES MELLITUS PO Adult Initially 25mg/day, may increase to TID based on tolerance, MD 50-100mg TID, may adjust dose q4-8wk intervals based on 1h PPG levels & tolerance max 50mg TID (<60 kg) or 100mg TID (>60 kg)

Contra: Hypersensitivity, DKA, cirrhosis, IBD, colonic ulceration, chronic intestinal diseases, renal impairment, type 1 DM, children & adolescent

Precautions: Increased hypoglycemic effects

ADR: Serious: edema, erythema, exanthema, hepatitis, ileus/subileus, jaundice, pneumatosis cystoides intestinalis, thrombocytopenia, urticaria, Others: rash, flatulence, increased transaminases, diarrhea, abdominal pain

DDI: Serious Colestyramine increases drug efficacy, Neomycin increases drug efficacy & GI adverse effects

Diet: With food (first bite of meal)

Monitor: PPG, HbA1c,LFT, SeCr

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