The Brand Name ADESERA Has Generic Salt :: Adefovir 

ADESERA  Is From Company Cipla Priced :: Rs. 600

ADESERA have Adefovir is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Herpes simplex virus, Chronic hepatitis B

Drug Dose ::

Adult: PO: The recommended dose of Adefovir for the treatment of chronic hepatitis B in adolescent & adults (age > 12 year) with adequate renal function is 10 mg, once daily, taken orally, without regard to food. Renal impairment: Haemodialysis patients: 10 mg every 7 days after dialysis. CrCl (ml/min) 20-49 10 mg every 48 hr. 10-19 10 mg every 72 hr. Dose Adjustment in Renal Impairment: Significantly increased drug exposures are seen when Adefovir Dipivoxil is administered to patients with renal impairment. Therefore, the dosing interval of Adefovir Dipivoxil should be adjusted in patients with baseline creatinine clearance < 50 mL/min using the following suggested guidelines- Dosing interval adjustment of Adefovir in patients with renal impairment Creatinine clearance (mL/min) > 50 20 to 49 10 to 19 < 10 Hemodialysis or CAPD Recommended dose and dosing interval 10 mg every 24 hours 10 mg every 48 hours 10 mg every 72 hours 10 mg every 7 days. Contraindication ::

Adefovir Dipivoxil is contraindicated in patients with previously demonstrated hypersensitivity to any of the components of the product.

Drug Precautions ::

Pregnancy; elderly; child; renal or hepatic impairment. HIV antibody testing to be performed before initiation due to possible resistance development in untreated HIV infection. Increased risk of hepatotoxicity in females, obese patients and with prolonged treatment. Monitor renal function every 3 mth; hepatitis B biochemical, viral and serological markers every 6 mth and LFTs. Discontinue therapy if liver function worsens, severe hepatomegaly, steatosis or unexplained metabolic or lactic acidosis. Monitor hepatic function for several mth in patients whose antihepatitis therapy is discontinued as acute exacerbations of hepatitis may occur.

Drug Side Effects ::

Nausea, dyspepsia, abdominal pain, flatulence, diarrhoea, asthenia, headache. Pruritus, skin rashes, and respiratory effects e.g. cough, pharyngitis and sinusitis.Potentially Fatal: Lactic acidosis, severe hepatomegaly with steatosis, hepatotoxicity, nephrotoxicity.

Pregnancy category ::

3

Drug Mode of Action ::  

Adefovir dipivoxil is an acyclic nucleoside reverse transciptase inhibitor. The diester function is hydrolyzed and subsequently phosphorylated to the active adefovir diphosphate. The active metabolite inhibits HBV DNA polymerase (reverse transcriptase) and hence inhibits viral replication. It can be used in patients with lamivudine-resistant hepatitis B.

Drug Interactions ::

Increased risk of nephrotoxicity with nephrotoxic drugs e.g. aminoglycosides, ciclosporin, NSAIDs, vancomycin, tacrolimus. Ibuprofen increases bioavailability of adefovir.