Albendazole

Details About Generic Salt ::  Albendazole 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Anthelmintics

13L. ANTHELMINTICS in 13. ANTI-INFECTIVES
ALBENDAZOLE
BENZIMIDAZOLE DERIVATIVE | ANTHELMINTIC
PK: A: Poor D: well inside hydatid cysts & CSF M: Hepatic E: Urine

Indications & Dose: ALVEOLAR ECHINOCOCCOSIS PO Adult >60 kg: 800mg/day in 2 divided doses 28 days followed by 14 tablet-free days, <60 kg: 15mg/kg/day in 2 divided doses, max 800mg 28 days followed by 14 tablet-free days & continued for months/years | ASCARIASIS Acute PO Adult 400mg single dose Child 12 month–2 yr: 200mg single dose, > 2 yr: Same as adult dose | CAPILLARIASIS Acute PO Adult 400mg/day 10 days Child >2 yr: same as adult dose | CYSTIC ECHINOCOCCOSIS Acute PO Adult >60 kg: 800mg/day in 2 divided doses 28 days followed by 14 tablet-free days, <60 kg: 15mg/kg/day in 2 divided doses, max 800mg 28 days followed by 14 tablet-free days, may be used 3 courses | ENTEROBIASIS Acute PO Adult 400mg single dose Child 12 month–2 yr: 200mg single dose, > 2 yr: Same as adult dose | GIARDIASIS Acute PO Adult 400mg single dose Child 12 month–2 yr: 200mg single dose, > 2 yr: Same as adult dose | HOOKWORM INFECT Acute PO Adult 400mg single dose Child 12 month–2 yr: 200mg single dose, > 2 yr: Same as adult dose | NEUROCYSTICERCOSIS Acute PO Adult >60 kg: 800mg/day BID 8–30 days, <60 kg: 15mg/kg/day BID, max 800mg 8–30 days | STRONGYLOIDIASIS Acute PO Adult 400mg OD/BID 3 days Child >2 yr: same as adult dose | TRICHOSTRONGYLIASIS Acute PO Adult 400mg single dose Child 12 month–2 yr: 200mg single dose, > 2 yr: Same as adult dose | TRICHURIASIS PO Adult Moderate infect: 400mg single dose, Severe infect: 400mg/day 3 days Child 12 month-2 yr: Moderate infect: 200mg single dose, Severe infect: Initially 200mg then 100mg BID 3 days, >2 yr: same as adult dose

Contra: Hypersensitivity

Precautions: Hepatic/renal impairment

ADR: Serious: ARF, hepatitis, thrombocytopenia, meningeal signs, rash, allergic shock if cyst leaks, urticaria, Others: fever, GI disturbances, headache, dizziness, alopecia, leukopenia, pancytopenia

DDI: Serious Levamisole decrease the drug bioavailability, Phenobarbital/Carbamazepine/Phenytoin decreases drug level, Dexamethasone increases drug level, Grapefruit juice increases the plasma levels of albendazole sulfoxide (drug metabolite), Cimetidine prolongs the half-life of drug

Diet: With high fat meal

Monitor: LFTs, CBC & ophthalmic exam

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