Alefacept

Details About Generic Salt ::  Alefacept 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

15G. ANTI-SEBORRHEICS in 15. SKIN
ALEFACEPT
MONOCLONAL ANTIBODY | IMMUNOSUPPRESSANT
PK: D: 0.094 L/kg (Vd) E: Cl: 0.25 mL/hr /kg

Indications & Dose: PLAQUE PSORIASIS Chronic/Mild-to-moderate IM Adult 15mg once weekly for 12 wk, initiate second course of therapy 12 wk after initial treatment if needed

Contra: Hypersensitivity, history of severe malignancy, patients with HIV infect/other important infect

Precautions: Hepatic/renal impairment

ADR: Serious: SJS, TEN, hepatitis, thrombocytopenia, lymphopenia, anaphylaxis, urticaria, Others: pruritus, chills, cough, Nausea, pharyngitis, dizziness, headache, myalgia

DDI: Serious Vaccines (Live & inactivated) effects are decreased, Pimecrolimus/Denosumab/Roflumilast/Tacrolimus/Trastuzumab increases drug effects, Natalizumab levels are increased, Alcohol may increase risk of liver toxicity

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