Alendronate

Details About Generic Salt ::  Alendronate 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Drugs affecting Bone Metabolism

8I. DRUGS AFFECTING BONE METABOLISM in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
ALENDRONATE
AMINOBISPHOSPHONATE | BONE RESORPTION INHIBITOR
PK: A: Poor D: 28 L (exclusive of bone) M: None E: Urine & feces

Indications & Dose: COMPLEX REGIONAL PAIN SYNDROME IV Adult 7.5mg/day 3 days | CORTICOSTEROID-INDUCED OSTEOPOROSIS PO Adult 5mg/day, in postmenopausal women not receiving HRT administer 10mg/day | PAGET’S DISEASE OF BONE PO Adult 40mg/day 6 months, may repeat if necessary after an interval of a further 6 months | POSTMENOPAUSAL OSTEOPOROSIS Prophylactic therapy PO Adult 5mg/day | POSTMENOPAUSAL OSTEOPOROSIS & OSTEOPOROSIS IN MEN PO Adult 10mg/day

Contra: Hypersensitivity, hypocalcemia, oesophagus abnormalities

Precautions: Upper GI disorders, disturbances of Ca & mineral metabolism, renal impairment

ADR: Serious: SJS, TEN, peptic ulceration, angioedema, atypical stress fractures, decrease electrolyte levels, gastritis, myalgia, Others: malaise, fever, abdominal pain, dyspepsia, regurgitation, nausea, vomiting, diarrhea, constipation, flatulence, headache

DDI: Serious Naproxen causes gastric mucosal damage, Antacids reduces drug absorption

Diet: Before food

Monitor: Osteoporosis, annual measurements of height/weight, chronic back pain & Serum Calcium

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