Alfacalcidol

Details About Generic Salt ::  Alfacalcidol 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Drugs affecting Bone Metabolism

8I. DRUGS AFFECTING BONE METABOLISM in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
ALFACALCIDOL
VIT D ANALOG | DRUGS AFFECTING BONE METABOLISM
PK: M: Hepatic

Indications & Dose: HYPOCALCEMIA PO Adult Initially 1µg/day, MD 0.25-1µg/day Child Premature infants & neonates: 0.05-0.1µg/kg/day, Children(<20 kg): 0.05µg/kg/day Elderly Initially 0.5µg/day, MD 0.25-1 µg/day | HYPOPARATHYROIDISM PO Adult Initially 1µg/day; MD 0.25-1µg/day Child Premature infants & neonates: 0.05-0.1µg/kg/day Children(<20 kg): 0.05µg/kg/day Elderly Initially 0.5µg/day; MD 0.25-1 µg/day | HYPOPHOSPHATEMIA PO Adult Initially 1µg/day; MD 0.25-1µg/day Child Premature infants & neonates: 0.05-0.1µg/kg/day Children(<20 kg): 0.05µg/kg/day Elderly Initially 0.5µg/day; MD 0.25-1 µg/day | OSTEOMALACIA PO Adult Initially 1µg/day; MD 0.25-1µg/day Child Premature infants & neonates: 0.05-0.1µg/kg/day Children(<20 kg): 0.05µg/kg/day Elderly Initially 0.5µg/day; MD 0.25-1 µg/day | PREVENTION OF VIT D DEFICIENCY IN RENAL/CHOLESTATIC LIVER DISEASE PO/IV Child Neonate: 0.02µg/kg OD, 1 month-12 yr (<20 kg): 0.015-0.03µg/kg OD (max 0.5µg), >20 kg: 0.25-0.5µg OD, 12-18 yr:0.25-0.5µg OD | RENAL OSTEODYSTROPHY PO Adult Predialysis: Initially 0.25µg/day 2 months, increase by 0.25µg/day q2months; MD: 0.5-1µg/day Dialysis:Initially 1µg/day 4 wks, increase by 0.5µg/day q2-4 wks; MD: 0.25-1µg/day | IV Adult Dialysis patients: Initially 1µg/dialysis (max 12µg/wk); MD: 1.5-12µg/wk | RICKETS PO Adult Initially 1µg/day; MD 0.25-1µg/day Child Premature infants & neonates: 0.05-0.1µg/kg/day Children(<20 kg): 0.05µg/kg/day Elderly Initially 0.5µg/day; MD 0.25-1 µg/day | SECONDARY HYPERPARATHYROIDISM PO Adult Initially 1µg/day; MD 0.25-1µg/day Child Premature infants & neonates: 0.05-0.1µg/kg/day; <20 kg: 0.05µg/kg/day Elderly Initially 0.5µg/day; MD 0.25-1µg/day

Contra: Hypersensitivity, hypercalcemia/hyperphosphatemia

Precautions: Renal impairment/calculi/heart disease, infants

ADR: Serious: cardiac arrhythmia, HTN, Others: headache, hyperthermia, pruritus, nocturia, hypercalcemia, hypercholesterolemia, anorexia, constipation, nausea, vomiting, hepatic enzyme elevated, myalgia, conjunctivitis, BUN elevated, polyuria, rhinorrhea

DDI: Serious Digoxin results in arrhythmias

Diet: With food

Monitor: Serum Ca, phosphate, Cr, BUN, albumin

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