Alfuzosin

Details About Generic Salt ::  Alfuzosin 

Main Medicine Class:: Genito Urinary System   Sub Medicine Class ::  Drugs For Prostate Disorders

10C. DRUGS FOR PROSTATE DISORDERS in 10. GENITO-URINARY SYSTEM
ALFUZOSIN
ALPHA1-ADRENERGIC RECEPTOR BLOCKER | DRUG FOR BPH
PK: A: Readily absorbed D: 3.2 L/kg (Vd) M: Hepatic E: Feces (69%) & urine (24%)

Indications & Dose: BENIGN PROSTATIC HYPERPLASIA PO Adult 2.5mg TID, may increase to 10mg/day if needed, Modified-release dose of 10mg OD after a meal Elderly 2.5mg BID | URINARY RETENTION Acute PO Elderly > 65 Yr: Modified-release preparation of 10mg/day 3-4daysAssociated with BPH

Contra: Hypersensitivity, concurrent use with potent CYP3A4 inhibitors

Precautions: Orthostatic hypotension, syncope, renal/hepatic impairment

ADR: Serious: angioedema, Postural hypotension, Others: syncope, dizziness, fatigue, headache, abdominal pain, constipation, dyspepsia, nausea, bronchitis, pharyngitis, sinusitis, diarrhea, edema, pruritus, rhinitis, rash

DDI: Serious Diuretics additive hypotensive effect, Diltiazem can raise the levels of both drugs, GA cause profound hypotension, β-blockers causes first-dose hypotension, ACEIs developing risk of postural hypotension after the first dose of the drug, Ketoconazole/Itraconazole/Ritonavir increases drug level

Diet: With food

Monitor: Urine flow & BP

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