Allopurinol

Details About Generic Salt ::  Allopurinol 

Main Medicine Class:: Musculoskeletal Disorders , Pain   Sub Medicine Class ::  Anti Gout Drugs

12B. ANTI-GOUT DRUGS in 12. MUSCULOSKELETAL DISORDERS & PAIN
ALLOPURINOL
XANTHINE OXIDASE INHIBITOR | ANTI-GOUT
PK: A: Rapid D: 1.6 L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: GOUT Severe Prophylactic therapy PO Adult Initially 100mg/day MD 700–900mg/day in divided doses | Mild Prophylactic therapy PO Adult Initially 100mg/day MD 100–200mg/day | Moderate-to-severe Prophylactic therapy PO Adult Initially 100mg/day MD 300–600mg/day in divided doses | HYPERURICAEMIA IN CANCER PATIENTS UNDERGOING CHEMOTHERAPY Prophylactic therapy PO Adult Initially 100mg/day MD 600-800mg/day in divided doses Child <15yr: 10–20mg/kg/day max 400mg/day | RECURRENT RENAL CALCULI PO Adult 200-300mg/day

Contra: Hypersensitivity, acute gout

Precautions: Ensure adequate fluid intake, hepatic/renal impairment

ADR: Serious: SJS, TEN, angioedema, hepatitis, pancreatitis, nephritis, jaundice, Others: nausea, headache, abdominal pain, alopecia, arthralgia, dyspepsia, fever, gastritis, vasculitis, paresthesia, pruritus, metallic taste, vomiting

DDI: Serious Aluminium hydroxide abolishes drug effect in hemodialysis patients, Thiazides causes severe allergic reactions, Chlorpropamide half-life increases, Mercaptopurine/Azathioprine hematological effects increased by drug, Ampicillin/Amoxicillin incidence of skin rashes is increased by drug, Phenytoin levels increased, ACEIs may increase the risk of leucopenia and serious infection especially in in renal impairment

Diet: With food

Monitor: CBC, serum uric acid levels, LFT & renal function test

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