Alprostadil

Details About Generic Salt ::  Alprostadil 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

11B. DRUGS FOR ERECTILE DYSFUNCTION/LIBIDO/INFERTILITY in 11. REPRODUCTIVE SYSTEM
ALPROSTADIL
PROSTAGLANDIN | DRUG FOR ERECTILE DYSFUNCTION
PK: D: Insignificant M: 75% E: Urine

Indications & Dose: ERECTILE DYSFUNCTION Adult Intracavernous: Individualize dose by careful titration, dose >60µg is not recommended | NEUROGENIC RELATED ERECTILE DYSFUNCTION Adult Intraurethral: Initially 125-250µg MD administer as needed to achieve an erection | Adult Intracavernous: Initially 1.25µg, increase by 2.5µg and then 5µg; increase further in increments 5µg until erection suitable for intercourse is achieved, not lasting >1 h, MD not more than 3 times/wk with at least 24 hrs between doses | PATENT DUCTUS ARTERIOSUS IV Child Inf: 0.05-0.1µg/kg/min, increase gradually in case of unsatisfactory response, MD 0.01-0.4µg/kg/minInfused into a large vein/ umbilical artery catheter placed at the ductal opening | VASCULOGENIC/PSYCHOGENIC/MIXED ERECTILE DYSFUNCTION Adult Intracavernous: Initially 2.5µg, increase by 2.5µg to dose of 5µg, further increase by 5-10µg until it causes an erection suitable for intercourse, not lasting >1h. If no response, second dose may be increased to 7.5µg followed by increments of 5-10µg

Contra: Hypersensitivity, hyaline membrane disease, persistent fetal circulation, respiratory distress syndrome, conditions predisposing priapism, anatomical deformation of penis & penile implants

Precautions: History of hemorrhage, neonates, congenital heart defects

ADR: Serious: penile edema, cortical proliferation, apnea, hypotension, cardiac arrest, hypokalemia & intravascular coagulation, convulsions, Others: headache, dizziness, diarrhea, back pain, fever, sinusitis, nasal congestion, cough, penile pain & urethral burning, flushing, phlebitis

DDI: Serious α-blockers leads to hypotension

Monitor: Arterial pressure, respiratory rate, HR, temperature