Ambrisentan

Details About Generic Salt ::  Ambrisentan 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

4H. MISCELLANEOUS in 4. CARDIOVASCULAR SYSTEM
AMBRISENTAN
ENDOTHELIN RECEPTOR ANTAGONIST | VASODILATOR
PK: A: Rapid E: Liver

Indications & Dose: PULMONARY HYPERTENSION PO Adult Initially 5mg OD, dose may be increased to 10mg OD

Contra: Moderate- to-severe hepatic impairment, patients with hypotension

Precautions: Avoid abrupt withdrawal

ADR: Serious: Hypotension, anaphylaxis, angioedema, anemia, muscle cramps, hepatic failure, hepatic cirrhosis, increases in liver aminotransferases, palpitations, flushing, Others: dizziness, GI disturbances, skin rashes, fatigue, pruritus, headache, nasopharyngitis

DDI: Serious Ketoconazole modestly increases drug level

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