The Brand Name AMPHEN Has Generic Salt :: Chloramphenicol
AMPHEN Is From Company Leben Priced :: Rs. 26.5
AMPHEN have Chloramphenicol is comes under Sub class Anti Infectives of Main Class Ocular
Main Medicine Class:: Ocular Sub Medicine Class :: Anti Infectives
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Indications for Drugs ::
Tetracycline-resistant cholera, typhoid, brain abscesses, meningitis, Granuloma inguinale, Anthrax, Listeriosis, Gas gangrene, Whipple’s disease, gastroenteritis, melioidosis, Plague, Psittacosis, Q fever, Tularaemia
Drug Dose ::
Adult: PO Susceptible infections 50 mg/kg/day in 4 divided doses, may increase to 100 mg/kg/day in more severe infections. Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections. Elderly: Hepatic impairment: Dose reduction may be required.
History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.
Drug Precautions ::
Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity.
Drug Side Effects ::
GI symptoms; bleeding; peripheral and optic neuritis, visual impairment, blindness; encephalopathy, confusion, delirium, mental depression, headache. Haemolysis in patients with G6PD deficiency. Potentially Fatal: Bone marrow suppression and irreversible aplastic anaemia. Neutropenia, thrombocytopenia. Grey baby syndrome. Rarely, anaphylaxis.
Pregnancy category ::
Drug Mode of Action ::
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Drug Interactions ::
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives. Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.