Amrinone

Details About Generic Salt ::  Amrinone 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Drugs for Cardiac Failure , Shock

4A. DRUGS FOR CARDIAC FAILURE & SHOCK in 4. CARDIOVASCULAR SYSTEM
AMRINONE
PHOSPHODIESTERASE ENZYME INHIBITOR | INOTROPIC, VASODILATOR
PK: M: Hepatic E: Urine (unchanged drug & metabolites)

Indications & Dose: INTRACTABLE HEART FAILURE IV Adult Loading dose 0.75mg/kg over 2-3min followed by MD 5-10µg/kg/min (as inf), loading dose may be repeat after 30min

Precautions: Severe obstructive aortic/pulmonary valvular disease, hypertrophic cardiomyopathy

ADR: Serious: Thrombocytopenia, hepatotoxicity, hypotension, cardiac arrhythmias, hypersensitivity reactions, Others: local pain, Headache, fever, chest pain, nail discoloration, decreased tear production

DDI: Serious Anagrelide increases inotropic effects

Monitor: BP, HR, fluid & electrolyte balance, platelet counts & LFTs

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