The Brand Name ANOLET Has Generic Salt :: LETROZOLE
ANOLET Is From Company Svizera Priced :: Rs. 135
ANOLET have LETROZOLE is comes under Sub class Anti Neoplastic Agents of Main Class Anti Neoplastic Agents
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
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Indications for Drugs ::
Drug Dose ::
Adult: PO Adjuvant therapy for post menopausal women with hormone receptor positive early breast cancer; Advanced breast cancer in postmenopausal women 2.5 mg once daily. Hepatic impairment: Reduce dose by 50% in patients with cirrhosis and severe hepatic impairment; recommended dose: 2.5 mg on alternate days.
Premenopausal women and children; hypersensitivity.
Drug Precautions ::
Severe renal impairment; severe hepatic impairment; osteoporosis. Caution when driving or operating machinery.
Drug Side Effects ::
Hot flushes, arthralgia, nausea, vomiting, fatigue, dizziness, headache, dyspepsia, constipation, diarrhoea, anorexia, alopoecia, increased sweating, rash, peripheral oedema, osteoporosis, musculoskeletal pain, vaginal irritation. Potentially Fatal: Thromboembolic events.
Pregnancy category ::
Drug Mode of Action ::
Letrozole competitively binds to the heme group of aromatase, a cytochrome P450 enzyme which catalyzes conversion of androgen to oestrogen, leading to inhibition of the enzyme and a significant reduction in plasma oestrogen levels.
Drug Interactions ::
Plasma levels reduced by tamoxifen.