Armodafinil

Details About Generic Salt ::  Armodafinil 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Nootropics , Neurotonics,Stimulants

1G. NOOTROPICS & NEUROTONICS/STIMULANTS in 1. NERVOUS SYSTEM
ARMODAFINIL
CNS STIMULANT | ANALEPTIC
PK: A: Readily absorbed D: Vd: 42 L M: Hepatic E: Urine (80% as metabolites, <10% as unchanged drug)

Indications & Dose: OBSTRUCTIVE SLEEP APNEA/HYPOPNEA SYNDROME (OSAHS) PO Adult 150-250mg OD in morning | SHIFT-WORK SLEEP DISORDER (SWSD) PO Adult 150mg as a single dose 1 hr prior to work shift Elderly Reduce dose

Contra: Hypersensitivity

Precautions: History of angina, cardiac ischemia, recent history of MI, left ventriclar hypertrophy, history of psychosis, renal/hepatic impairment, elderly, child <17yrs

ADR: Serious: GGT increased, paresthesia, flu like syndrome, anaphylactoid reactions, increased liver enzymes, pancytopenia, systolic BP, Others: Headache, dizziness, fatigue, depression, anxiety, insomnia, rash, contact dermatitis, nausea, diarrhea, constipation, anorexia, appetite decreased, loose stools, polyuria

DDI: Others CYP3A4 Inducers decreases armodafinil levels, Cannabinoids/Atomoxetine/CYP3A4 Inhibitors increases armodafinil levels, Clopidogrel/Ciclosporin/Estrogen levels decreases, Sympathomimetics levels increase

Diet: With/without food

Monitor: Signs of hypersensitivity, rash, psychiatric symptoms, BP, drug abuse, levels of sleepiness

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