Azithromycin

Details About Generic Salt ::  Azithromycin 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Macrolides

13E. MACROLIDES in 13. ANTI-INFECTIVES
AZITHROMYCIN
MACROLIDE ANTIBIOTIC | ANTI-INFECTIVE
PK: A: Rapid D: Extensive M: Hepatic E: Biliary, urine

Indications & Dose: BACTERIAL SINUSITIS PO Adult 500mg/day for a total of 3 days Child > 6 months: 10mg/kg OD 3 days, max 500mg/day, >16 yr: Same as adult dose | CHANCROID PO Adult 1g single dose | CHOLERA PO Adult 1g single dose | COMMUNITY-ACQUIRED PNEUMONIA PO Adult 500mg single dose on day 1, then 250mg OD on days 2-5, Suspension ER: 2g single dose Child Day 1: 10mg/kg, max 500mg/day, then 5mg/kg/day on days 2-5, max 250mg/day, Suspension ER:<34 kg: 60mg/kg as single dose, >34 kg: Same as adult dose | EXACERBATION OF CHRONIC BRONCHITIS Acute/Mild-to-moderate PO Adult 500mg OD 3 days | GENITAL CHLAMYDIAL INFECT Uncomplicated PO Child 12–18 yr: 1g single dose | GENITAL CHLAMYDIAL INFECTIONS PO Child 12–18 yr: 1g single dose | GONOCOCCAL INFECTION Uncomplicated Combination therapy Adult 1g single dose with cephalosporincervix, pharynx, rectum, urethra | GONOCOCCAL URETHRITIS/CERVICITIS Mono therapy PO Adult 2g single dose | GRANULOMA INGUINALE PO Adult 1g/wk for at least 3 wk & until lesions have healed Child > 16 yr: Same as adult dosedonovanosis | INFECT IN CYSTIC FIBROSIS PO Child 6 months–18 yr: 10mg/kg/day, max 500mg/day 3 days, course repeated after 1 wk, then repeat as necessary | MYCOBACTERIUM AVIUM COMPLEX INFECT Prophylactic therapy PO Adult 1.2g once weeklyin advanced HIV infection | NON-GONOCOCCAL URETHRITIS PO Adult 1g single dose Child 12–18 yr: 1g single dose | OTITIS MEDIA PO Child > 6 months: 10mg/kg/day, max 500mg/day 3 days | PELVIC INFLAMMATORY DISEASE IV Adult 500mg single dose for first 2 days, 250mg/day PO to complete 1wk course of therapy Child >16 yr: Same as adult dose | PERTUSSIS PO Adult 500mg on day 1 followed by 250mg/day on days 2-5, max 500mg/day Child <6 months: 10mg/kg/day 5 days, >6 months: 10mg/kg on day 1, max 500mg/day then 5mg/kg/day on days 2-5, max 250mg/day, >16 yr: Same as adult dose | PHARYNGITIS/TONSILLITIS PO Adult 500mg single dose on day 1, then 250mg OD on days 2-5 Child >2 yr: 12mg/kg/day 5 days, max 500mg/day | PULMONARY MAC INFECT Combination therapy PO Adult 500-600mg thrice weekly with ethambutol & rifampicin | RECURRENT URETHRITIS Combination therapy PO Adult 1g single dose with metronidazole/tinidazole | RESPIRATORY TRACT INFECT Mild-to-moderate PO Adult Loading dose: 500mg as single dose on day 1, then 250mg/day as single dose on days 2-5 Child >6 months: 10mg/kg/day, max 500mg/day 3 days, >16 yr: Same as adult dose | SEXUALLY-TRANSMITTED DISEASES AFTER SEXUAL ASSAULT Combination therapy/Prophylactic therapy PO Adult 1g single dose with a cephalosporin & metronidazole Child >16 yr: Same as adult dose | SKIN & SOFT TISSUE INFECT PO Adult Loading dose: 500mg single dose on day 1, then 250mg/day as single dose on days 2-5 Child >6 months: 10mg/kg/day, max 500mg/day 3 days, >16 yr: Same as adult dose | URETHRITIS/CERVICITIS Adult 1g single dose Child >16 yr: Same as adult dose

Contra: Hypersensitivity, porphyria

Precautions: Hepatic impairment, myasthenia gravis, QT interval prolongation agents, history of arrhythmias, use of lactobionate in patients with severe renal impairment

ADR: Serious: Angioedema, photosensitivity, bronchospasm, nephritis, palpitation, Others: rhinitis, diarrhea, nausea, pruritus, rash, abdominal pain, anorexia, vomiting, vaginitis, inflammation, allergic reaction, candidiasis, conjunctivitis, fungal infect, insomnia, constipation, flatulence, diaphoresis, dizziness, leukopenia, malaise, nervousness, taste perversion

DDI: Serious Lovastatin leads to acute rhabdomyolysis, Digoxin/Ciclosporin levels increases, Antacids reduce drug levels

Diet: With/without food

Monitor: CBC, LFTs