Aztreonam

Details About Generic Salt ::  Aztreonam 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Other Beta Lactams

13D. OTHER BETA LACTAMS in 13. ANTI-INFECTIVES
AZTREONAM
MONOBACTAM | ANTI-INFECTIVE
PK: A: Well absorbed D: Children: 0.2-0.29 L/kg, Adults: 0.2 L/kg (Vd) M: Hepatic E: Urine, feces

Indications & Dose: CYSTIC FIBROSIS IV Child 50mg/kg/dose q6-8h, max 8g/day | Inh Adult Nebulizer: 75mg TID (at least 4h apart) 4 wk & stop the treatment, do not repeat for 28 days after completion Child >7 yr: Same as adult dose | INFECT Mild-to-moderate IV/IM Child > 1 month: 30mg/kg TID | Moderate-to-severe IV/IM Child > 1 month: 30mg/kg q6-8h, max 120mg/kg/day (8g/day) | LIFE-THREATENING INFECT IV Adult 2g TID/QID, max 8g/day caused by P. aeruginosa | MENINGITIS IV Adult 2g q6-8h for Gram-negative Child <7 days: 30mg/kg over 3-5min BID, Neonate: 7-28 days: 30mg/kg over 3-5min TID/QID, 1 month-12 yr: 30mg/kg over 3-5min TID/QID, 12-18 yr: 1g TID or 2g BID Gram-negative | SYSTEMIC INFECT Moderate-to-severe IV Adult 1-2g BID/TID | IM Adult 2g q6-8h, max 8g/day for severe or life threatening infect | URINARY TRACT INFECT IV/IM Adult 0.5-1g q8-12h

Contra: Hypersensitivity

Precautions: Renal/hepatic impairment

ADR: Serious: Hypersensitivity reactions, angioedema, anaphylaxis, TEN, bronchospasm, thrombophlebitis, GI bleeding, pseudomembranous colitis, jaundice, hepatitis, increases liver enzymes, Others: prolongation of PT interval, skin rashes, urticaria, exfoliative dermatitis, eosinophilia

DDI: Serious Coumarins increased risk of hemorrhage

Monitor: Signs of anaphylaxis during first dose, periodic LFTs, FEV1

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