Bezafibrate

Details About Generic Salt ::  Bezafibrate 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Fluid , Electrolyte Preparations

4F. ANTI-HYPERLIPIDEMICS in 4. CARDIOVASCULAR SYSTEM
BEZAFIBRATE
LIPID REGULATOR (FIBRIC ACID DERIVATIVE) | ANTI-HYPERLIPIDEMIC
PK: A: Rapid D: ~17 L M: Hepatic E: Urine, feces

Indications & Dose: HYPERLIPIDEMIA PO Adult 200mg TID, dose may increased gradually over 5-7 days, MD 200mg BID, Modified-release tablet: 400mg/day as single dose Child 10–18 yr: 200mg OD, max 200mg TID

Contra: Hypersensitivity, photoallergic/phototoxic reactions to fibrates, primary biliary cirrhosis, hepatic impairment, renal impairment (SeCr >1.5mg/dL, Clcr <60mL/min), pre-existing gallbladder disease, concomitant use with HMG CoA reductase inhibitors, type I hyperlipoproteinemia

Precautions: hypoalbuminemia/nephrotic syndrome, history of jaundice/hepatic disorder

ADR: Serious: ARF, SJS, TEN, rhabdomyolysis, pancytopenia, decrease platelets count, thrombocytopenia purpura, Others: Gastric discomfort, headache, dizziness, vertigo, fatigue, skin rashes, pruritus, photosensitivity, alopecia, impotence, GI disturbances, anorexia, nausea

DDI: Serious Coumarins effects increases, Nifedipine leads to rhabdomyolysis, Colestyramine reduce drug absorption

Diet: After food

Monitor: Lipid profile, LFT, CBC

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