Details About Generic Salt ::  Bicalutamide 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
BICALUTAMIDE
NONSTEROIDAL ANTI-ANDROGEN | ANTI-NEOPLASTIC
PK: A: Rapid & complete M: Hepatic E: Urine (36%, as inactive metabolites), feces (42%, as unchanged drug & inactive metabolites)

Indications & Dose: METASTATIC PROSTATE CANCER Combination therapy/Palliative therapy PO Adult 50mg/day with gonadotropin releasing hormone analog

Contra: Hypersensitivity, suspected pregnancy

Precautions: Moderate-to-severe hepatic dysfunction

ADR: Serious: Peripheral edema, angina, HF, arrhythmias, ECG changes, interstitial pneumonitis, pulmonary fibrosis, hypersensitivity reactions, angioedema, hypercholesterolemia, libido decreased, gout, hepatotoxicity, anemia, Others: Pruritus, asthenia, alopecia, hair regrowth, dry skin, urticaria, hyperglycemia, dehydration, pelvic pain, hematuria, nocturia, constipation, nausea, diarrhea, abdominal pain, dyspnea

DDI: Serious Warfarin anticoagulant effect increases, Midazolam levels increases

Diet: With/without food

Monitor: CBC, ECG, echocardiograms, serum testosterone, luteinizing hormone, and prostate specific antigen, LFTs, signs & symptoms of liver dysfunction, PT

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