Bleomycin

Details About Generic Salt ::  Bleomycin 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
BLEOMYCIN
CYTOTOXIC GLYCOPEPTIDE ANTIBIOTIC | ANTI-NEOPLASTIC
PK: A: Rapid (parenteral, intraperitoneal, intrapleural) D: 22 L/m2 (Vd) M: Hepatic, GI tract, skin, pulmonary, renal & Se E: Urine (50%-70% as active drug)

Indications & Dose: HODGKIN’S LYMPHOMA IV/IM/SC Adult 10-20U/m2 once/twice weekly, after 50% response, MD 1U/m2/day (IM/IV) or 5U/m2/wk (IM/IV) | MALIGNANT PLEURAL EFFUSION Intrapleural Adult 50-60U dissolved in 50-100mL of Nacl (0.9%), given through thoracostomy tube | SQUAMOUS CELL CARCINOMA OF HEAD/NECK/SKIN/PENIS/CE IV/IM/SC Adult 10-20U/m2 once/twice weekly | TESTICULAR CARCINOMA IV/IM/SC Adult 10-20U/m2 once/twice weekly

Contra: Hypersensitivity

Precautions: Renal impairment, elderly, pulmonary infect, pre-existing impairment of pulmonary function, use of oxygen during surgery

ADR: Serious: cardiorespiratory collapse, Pulmonary toxicity, interstitial pneumonitis fibrosis, thrombophlebitis, acute anaphylactoid reactions, TEN, Others: onycholysis, anorexia, weight loss, local reactions, rash, erythema, pruritus, vesiculation, hyperkeratosis, nail changes, alopecia, hyperpigmentation, striae, stomatitis, fever, hyperpyrexia

DDI: Serious Vinblastine causes Raynaud’s phenomenon, Cisplatin increases pulmonary toxicity of drug by reduces its renal excretion, Colony-stimulating factors induces pulmonary toxicity of drug, Oxygen leads to serious & potentially fatal pulmonary toxicity, Phenytoin levels reduced

Monitor: Pulmonary function tests, renal function, LFTs, chest x-ray, temp, body weight at regular intervals