Indications & Dose: ADVANCED PROSTATIC CARCINOMA SC Adult 500µg q8hrs for 1wk. (On 8th day treatment is changed to nasal route; 100µg is sprayed into each nostril 6times/day | ENDOMETRIOSIS NSL Adult 150µg sprayed into each nostril 3times/day for 6months | INFERTILITY NSL Adult 150µg 4times/day, start therapy either in early follicular phase (day 1) or mid luteal phase (day 21) of menstrual cycle, and therapy should continue until pituitary downregulation (usual range 1-3 wks), max 300µg 4times/day. Alternatively 200-500µg/day, max 500µg BID as SC

Precautions: Not to be use in pituitary adenoma , PCOS , endometriotic cysts patients, DM, hypertension, depression

ADR: Serious: Depot inj: impotence, libido decreased; SC/Intranasal: edema, palpitation, breast pain, hirsutism, menstrual disorder, premenstrual syndrome, gynecomastia, myalgia, arthralgia, Others: Depot inj: hot flushes, weakness, dizziness, depression, pain, nausea, appetite increased, insomnia, local site reaction, SC/Intranasal: fever, dizziness, depression, insomnia, bruising, erythema, skin disorder, nausea, vomiting, constipation, acne, dry skin, flare reaction, taste perversion, weight loss/gain, vaginitis, vaginal discharge, pelvic pain, weakness, back pain, neck rigidity, URTI, dry nose, rhinitis, diaphoresis, infection

DDI: Others Antidiabetics level decreases

Monitor: Se testosterone levels, Se estradiol levels, prostate specific antigen, prostatic acid phosphatase, blood glucose levels, bone scan,CT scan, digital rectal exam, BP, mood changes, ultrasound