Details About Generic Salt ::  Cabergoline 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Drugs for Neurodegenerative Disorders

8K. MISCELLANEOUS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
CABERGOLINE
DOPAMINE (D2) AGONIST, PROLACTIN INHIBITOR | ANTI-PARKINSONIAN, DRUG FOR HYPERPROLACTINEMIA
also comes under 1F. Drugs for Neurodegenerative Disorders in 1. Nervous System,  
PK: D: Extensive M: Hepatic E: Feces, urine

Indications & Dose: HYPERPROLACTINEMIC DISORDERS PO Adult Initially 0.25mg twice weekly, increase by 0.25mg twice weekly, max 1mg twice weekly based on serum prolactin level, dose increments q4wk. Discontinue if normal serum prolactin level is maintained for 6 monthsEither idiopathic/due to pituitary adenomas | PARKINSON’S DISEASE PO Adult Initially 0.5mg OD as monotherapy or 1mg in adjunctive therapy, dose increments of 0.5 or 1 mg q7 or 14 days, max 3mg/day | SUPPRESSION OF ESTABLISHED LACTATION PO Adult 250µg q12h 2 days | TO INHIBIT PHYSIOLOGICAL LACTATION PO Adult 1mg as single dose on first day of postpartum

Contra: Hypersensitivity, uncontrolled HTN, postpartum/puerperium in women with HTN, symptoms/history of serious psychiatric disorders, ergot alkaloids during the puerperium, glucose-galactose malabsorption

Precautions: CVD, Raynaud’s syndrome, history of psychosis, hepatic impairment, renal disease, HTN, pituitary tumor, galactose intolerance, severe lactose deficiency

ADR: Serious: CVA, arrhythmias, bradycardia, acute MI, GI hemorrhage, hypotension, blurred vision, diplopia, Others: nausea, vomiting, diarrhea, constipation, abdominal cramps, anorexia, dry mouth, urinary incontinence, polyuria, urinary retention, leg cramps, urticaria, rash, Headache, dizziness, fatigue, mania, insomnia, palpitations, extrasystoles

DDI: Serious Macrolides increases drug levels, Metoclopramide reduces drug effect

Diet: With food

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