Candesartan

Details About Generic Salt ::  Candesartan 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Hypertensives

4A. DRUGS FOR CARDIAC FAILURE & SHOCK in 4. CARDIOVASCULAR SYSTEM
CANDESARTAN
ANGIOTENSIN II RECEPTOR ANTAGONIST | ANTI-HYPERTENSIVE
also comes under 4D. Anti-Hypertensives in 4. Cardiovascular System,  
PK: A: Rapid D: 0.13 L/kg (Vd) M: Intestinal wall E: Urine, Bile

Indications & Dose: HEART FAILURE PO Adult Initially 4mg OD, may double the dose at 2wk intervals, target dose 32mg/day Elderly Same as adult dose | HYPERTENSION PO Adult 16mg OD max 8-32mg/day Elderly Same as adult dose

Contra: Hypersensitivity, severe hepatic impairment, cholestasis, concurrent use of potassium-sparing diuretics

Precautions: Seizures, bipolar disorder/psychoses, history of CVD, hepatic/renal impairment, renal artery stenosis, volume depletion (high-dose diuretic therapy)

ADR: Serious: Angina, hypotension, MI, tachycardia, angioedema, increased SeCr, dyspnea, renal failure, rhabdomyolysis, blood disorder, hematuria, abnormal hepatic function, Others: urticaria, back pain, CPK increased, URTI, increased diaphoresis, dizziness, light-headedness, drowsiness, headache, vertigo, anxiety, depression, somnolence, palpitation, fever, rash, hyperglycemia, hyperkalemia, hypertriglyceridemia, hyperuricemia, dyspepsia

DDI: Serious Lithium toxicity occurs

Diet: With/without food

Monitor: Supine BP, electrolytes, Secr, BUN, urinalysis, symptomatic hypotension, serum K+ & tachycardia

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