Cefdinir

Details About Generic Salt ::  Cefdinir 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Cephalosporins

13B. CEPHALOSPORINS in 13. ANTI-INFECTIVES
CEFDINIR
THIRD GENERATION CEPHALOSPORIN | ANTI-INFECTIVE
PK: D: Children: 0.29-1.05L/kg (Vd) & adults: 0.06-0.64L/kg (Vd) E: Urine(7-25% as unchanged drug)

Indications & Dose: COMMUNITY-ACQUIRED PNEUMONIA PO Adult 300mg BID 10 days Child >13 yr: Same as adult dose | EXACERBATION OF CHRONIC BRONCHITIS PO Adult 300mg BID 5-10 days or 600mg OD 10 days Child >13 yr: Same as adult dose | MAXILLARY SINUSITIS Acute PO Adult 300mg BID or 600mg OD 10 days Child 6 months-12 yr: 7mg/kg BID or 14mg/kg OD 10 days, >13 yrs: Same as adult dose | OTITIS MEDIA Acute PO Child 6 months-12 yr: 7mg/kg BID 5-10 days or 14mg/kg OD 10 days | PHARYNGITIS/TONSILLITIS Emergency therapy PO Adult 300mg BID 5-10 days or 600mg OD 10 days Child 6-12 yr: 7mg/kg BID 5-10 days or 14 mg/kg OD 10 days, >13 yr: Same as adult dose | SKIN/SKIN STRUCTURE INFECT Uncomplicated PO Adult 300mg BID 10 days Child >13 yr: Same as adult dose | Mild-to-moderate PO Child 6 months-12 yr: 7mg/kg BID 10 days

Contra: Hypersensitivity to cephalosporins

Precautions: Penicillin-sensitive patients, history of allergy, renal impairment, false Jaffé method of measuring creatinine level, false positive Coombs’ test, false-positive reactions for glucose using copper-reduction reactions

ADR: Serious: Hypersensitivity reactions, Blood disorders, anaphylaxis, bleeding complications, hypoprothrombinemia, acute interstitial nephritis, cholestatic jaundice, CNS toxicity, convulsions, overgrowth of non-susceptible organisms, Others: Skin rashes, urticaria, nausea, vomiting, thrombophlebitis

DDI: Serious Ferrous Sulphate/Antacids markedly reduces drug absorption

Diet: With/without food

Monitor: Renal & hematological status, signs of anaphylaxis (first dose)