Chlorambucil

Details About Generic Salt ::  Chlorambucil 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
CHLORAMBUCIL
ALKYLATING AGENT, NITROGEN MUSTARD | ANTI-NEOPLASTIC, IMMUNOSUPPRESSANT
also comes under 14A. Immunuosuppressants in 14. Immunology & Allergy
PK: A: Rapid & complete D: 0.14-0.24 L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: HODGKIN’S LYMPHOMA PO Adult 0.2mg/kg/day for 3-6 wks | NEPHROTIC SYNDROME Combination therapy PO Adult 0.1-0.2mg/kg/day for 8-12 wk with low dose prednisone | NON-HODGKIN LYMPHOMA/ CHRONIC LYMPHOCYTIC LEUKEMIA PO Adult 0.1mg/kg/day for 3-6 wks Child Initiate with lower doses

Contra: Hypersensitivity, hypersensitivity to other alkylating agents

Precautions: History of seizure disorder/head trauma, avoid/with low dose for at least 4 wks after radiotherapy or other antineoplastics, renal/hepatic impairment, acute infect

ADR: Serious: Hepatotoxicity, SJS, TEN, peripheral neuropathy, central neurotoxicity, interstitial pneumonia, pulmonary fibrosis, seizures, infertility, SIADH, blood disorders, bone marrow depression, azoospermia, cystitis, Others: Angioneurotic edema, erythema multiforme, amenorrhea, hallucinations, agitation, ataxia, drug fever, muscular twitching, allergic reactions, diarrhea, nausea, vomiting, oral ulceration, urticaria

DDI: Serious Vaccines (Live) immune response is impaired & leads to generalized infect, Ciclosporin levels reduced

Monitor: LFTs, CBC, serum uric acid