Chlorpromazine

Details About Generic Salt ::  Chlorpromazine 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Psychotics

7D. ANTI-EMETICS in 7. GASTROINTESTINAL SYSTEM
CHLORPROMAZINE
PHENOTHIAZINE | ANTI-PSYCHOTIC, ANTI-EMETIC
also comes under 1E. Anti-Psychotics in 1. Nervous System,  
PK: A: Rapid D: 20L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: CONTROL OF NAUSEA AND VOMITING PO Adult 10-25mg q4-6h Child 1-6 yr: 500µg/kg q4-6h max 40mg/day, 6-12 yr: 500µg/kg q4-6h max 75mg/day, 12-18 yr: 10-25mg q4–6h Elderly 10-25mg OD/BID, increase at 4-7day intervals by 10-25mg/day, max 800mg/day | IM Adult 25-50mg q4-6h Child 1-6 yr: 500µg/kg q6–8h max 40mg/day, 6-12 yr: 500µg/kg q 6–8h max 75mg/day, 12-18 yr: 25-50mg q3-4h | INTRACTABLE HICCUPS PO/IM Adult 25-50mg TID/QID 2-3 days | SCHIZOPHRENIA/PSYCHOSES PO Adult 30-800mg/day in 1-4 divided doses, initiate at lower doses & titrate as needed, usual dose 200-600mg/day, some patients may require 1-2g/day Child 1-6 yr: 500µg/kg q4-6h adjusted according to response max 40mg/day, 6-12 yr: 10mg TID, adjusted according to response, max 75mg/day, 12-18 yrs: 25mg TID or 75mg HS adjusted according to response. MD 75-300mg/day Elderly One-third to one-half the usual adult dose

Contra: Hypersensitivity, severe CNS depression, coma, pheochromocytoma, prolactin-dependent tumours

Precautions: Asthma, peptic ulcer, bradycardia, arrhythmias, recent coronary occlusion, hyperthyroidism, seizures, cerebrovascular diseases, parkinsonism, DM, myasthenia gravis, paralytic ileus, history of jaundice, angle-closure glaucoma, renal/hepatic impairment, elderly, presence of acute infect/leucopenia

ADR: Serious: NMS, seizures, hepatitis, tachycardia, hypotension, blurred vision, gynecomastia, blood disorders, pseudoparkinsonism, Others: sedation, drowsiness, EPS, tardive dyskinesia, dry eyes, nasal congestion, constipation, anorexia, dry mouth, urinary retention, priapism, galactorrhea, sterile abscess, allergic reactions, hyperthermia, menstrual irregularities, pain at Inj site

DDI: Serious Charcoal/Antacids decreases drug absorption, Guanethidine efficacy is abolished by drug, Valproic acid elimination decreases & effects increases, Barbiturates increases drug metabolism & decreases its efficacy, TCAs levels & effects increases, Phenytoin loweres seizure threshold, GA/Antihistamines/MAOIs/Sedatives/hypnotics results in additive CNS depression, Lithium results in disorientation, loss of consciousness, extrapyramidal symptoms, Meperidine results in excessive sedation & hypotension

Diet:

Monitor: Lipid profile, FBG/Hgb A1c, BMI, mental status, AIMS, EPS, CBC

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