Cimetidine

Details About Generic Salt ::  Cimetidine 

Main Medicine Class:: Gastrointestinal System   Sub Medicine Class ::  GERD,

7A. GERD, ULCER/ANTACIDS in 7. GASTROINTESTINAL SYSTEM
CIMETIDINE
H2-RECEPTOR ANTAGONIST | ANTI-ULCER
PK: A: Rapid D: 1.3L/kg (Vd) M: Hepatic E: Urine, feces

Indications & Dose: ACTIVE ULCERS Active disease Short-term therapy PO Adult 300mg QID or 800mg at HS or 400mg BID up to 8 wk | GASTRIC HYPERSECRETORY CONDITIONS PO Adult 300-600mg q6h max 2.4g/day | GASTROESOPHAGEAL REFLUX DISEASE PO Adult 400mg QID or 800mg BID 12 wk | H.PYLORI INFECT Prophylactic therapy PO Adult 400mg at HS | HEART BURN/ACID INDIGESTION/ SOUR STOMACH PO Adult 200mg BID Child >12yr: 200mg BID | PANCREATIC INSUFFICIENCY PO Adult 0.8-1.6g/day in 4 divided doses | ZOLLINGER-ELLISON SYNDROME PO Adult 300 or 400mg QID,

Contra: Hypersensitivity

Precautions: Hepatic/renal impairment, cardiovascular impairment

ADR: Others: Confusion, dizziness, drowsiness, hallucinations, agitation, psychosis, depression, anxiety, headache, diarrhea, reversible erectile dysfunction, pain at IM Inj site, gynecomastia

DDI: Serious Anti-neoplastics leads to neutropenia, agranulocytosis, Lidocaine/Benzodiazepines/Metronidazole/Phenytoin/Propranolol/TCAs/Terfenadine/Theophylline/Triamterene/Warfarin levels increases & decreases their elimination, Alcohol levels raises by drug, Magnesium Hydroxide/Aluminium hydroxide reduces drug absorption

Monitor: CBC, gastric pH, occult blood with GI bleeding, renal function

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