Cinacalcet

Details About Generic Salt ::  Cinacalcet 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Drugs affecting Bone Metabolism

8I. DRUGS AFFECTING BONE METABOLISM in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
CINACALCET
CALCIMIMETIC
PK: D: Vd: ~ 1000 L M: Hepatic E: Urine (~80%), feces (~15%)

Indications & Dose: HYPERCALCEMIA PO Adult Initially 30mg BID, may increase dose sequentially at intervals of 2-4 wks to max 90mg TID-QID in patients with parathyroid carcinoma or primary hyperparathyroidism | SECONDARY HYPERPARATHYROIDISM IN DIALYSIS PO Adult Initially 30mg/day, may increase at intervals of 2-4 wks by 30mg to max 180mg/day in patients with CKD on dialysis

Contra: Hypersensitivity

Precautions: Moderate to severe hepatic impairment, decreased serum calcium level, history of seizures, CVD

ADR: Serious: Hypocalcaemia and adynamic bone disease, myalgia, paraesthesia, hypertension, hypersensitivity reactions, chest pain, hypotension, worsening heart failure, Others: asthenia, anorexia, rashes, GI disturbances, nausea, vomiting, diarrhea

DDI: Others Rifampicin decreases cinacalcet level, Ketoconazole/CYP3A4 Inhibitors increases cinacalcet adverse effects, CYP1A2 Inhibitors increases cinacalcet level, Tacrolimus level decreases, TCAs/Dextromethorphan level increases

Diet: With food/after meals

Monitor: Se Ca, Ph & PTH levels

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