Clobazam

Details About Generic Salt ::  Clobazam 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Epileptics

1C. ANTI-EPILEPTICS in 1. NERVOUS SYSTEM
CLOBAZAM
BENZODIAZEPINE | ANTI-EPILEPTIC, ANXIOLYTIC
also comes under 1B. Anxiolytics in 1. Nervous System
PK: A: Rapid M: Hepatic E: Urine

Indications & Dose: ANXIETY Acute Short-term therapy PO Adult 20–30mg/day in single or divided doses HS max 60mg/day Elderly 10–20mg/day | EPILEPSY Adjuvant therapy PO Adult 20-30mg/day max 60mg/day Child 3-12 yr: Initially 125µg/kg BID & increase dose q5days, MD 250µg/kg BID max 500µg/kg BID, 12–18 yr: Initially 10mg BID & increase dose q5days, MD 10–15mg BID max 30mg BID

Contra: Respiratory depression, acute pulmonary insufficiency, sleep apnea, hepatic impairment, myasthenia gravis, inj containing benzyl alcohol in neonates

Precautions: History of alcohol/drug abuse, marked personality disorder, avoid abrupt withdrawal, porphyria

ADR: Serious: Respiratory depression, hypotension, jaundice, Others: phlebitis, drowsiness, fatigue, muscle weakness, ataxia, confusion, vertigo, constipation, dizziness, insomnia, irritability, libido, urinary retention

DDI: Serious Carbamazepine decreases drug level, Alcohol increases drug level, Stiripentol increases drug levels, Valproic acid/Phenytoin levels are increased

Diet: With/without food

Monitor: BP, cardiovascular & CNS status, respiratory, CBC, LFTs, renal function, TFT

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