Colistin sulphate

Details About Generic Salt ::  Colistin sulphate 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

13Q. PEPTIDES in 13. ANTI-INFECTIVES
COLISTIN SULPHATE
POLYMYXIN DERIVATIVE | ANTI-INFECTIVE
PK: A: Poor E: Urine

Indications & Dose: BOWEL STERILISATION PO Adult 1.5–3MU q8h | IV Adult <60 kg: 50, 000–75, 000U/kg/day in 3 divided doses, >60 kg: 1–2MU q8h Child Same as adult dose | RESPIRATORY INFECT Adjunct therapy Inh Adult 1–2MU q12h Child >2 yr:1–2MU q12h, <2 yr: 0.5–1MU q12hTo standard antibacterial therapy in patients with cystic fibrosis

Precautions: Renal impairment, cystic fibrosis, neonates

ADR: Serious: Hypersensitivity reactions, overgrowth of nonsusceptible organisms, visual disturbances, bronchospasm, Others: pain, local irritation, neurotoxic reactions, transient sensory disturbances, cough

DDI: Serious Cefalotin leads to renal failure, Neuromuscular blockers neuromuscular blockade activity is increased & prolonged