Cyproterone , Ethinyl estradiol

Details About Generic Salt ::  Cyproterone , Ethinyl estradiol 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

15K. DRUGS FOR ACNE in 15. SKIN
CYPROTERONE + ETHINYL ESTRADIOL
PROGESTOGEN | ANTI-ACNE, CONTRACEPTIVE
also comes under 11A. Contraceptive Drugs in 11. Reproductive System
PK: A: Rapid & complete M: Hepatic E: Urine & feces

Indications & Dose: ACNE/HIRSUTISM PO Adult 2mg cyproterone acetate with 35µg ethinylestradiol OD for 21 days of each menstrual cycle followed by 7 drug free days. 1st tablet should be initiated on the first day of menstrual flow. Discontinue therapy 3-4 cycles after symptoms have resolved | CONTRACEPTION PO Adult 2mg cyproterone acetate with 35µg ethinylestradiol OD for 21 days of each menstrual cycle followed by 7 drug free days. 1st tablet should be initiated on the first day of menstrual flow. Discontinue therapy 3-4 cycles after symptoms have resolved

Contra: Hypersensitivity, history of /current thrombophlebitis, Stroke/MI, CVD, complicated valvular heart disease, severe HTN, DM with vascular involvement, known/suspected breast carcinoma, endometrial cancer, hepatic dysfunction, major surgery with prolonged immobilization, chronic smokers

Precautions: should not be used with other oral contraceptives, renal impairment, conditions that may be aggravated by fluid retention, depression, history of migraine

ADR: Serious: arterial thromboembolism, cerebral hemorrhage/thrombosis, MI, HTN, stroke, dysmenorrhea, breast tenderness, thrombophlebitis, Others: headache, dizziness, migraine, abdominal cramp, vomiting, nervousness, bloating, rash

DDI: Serious Artemether/Aminoglutethimide/Carbamazepine/Griseofulvin/Mycophenolate decreases drug level, HIV protease inhibitors decreases PI level, Corticosteroids/Benzodiazepines/Ropinirole/Selegiline/Tranexamic acid/Voriconazole levels increases

Diet: After food

Monitor: Signs & symptoms of VTE, BP, breast exam, pap smear, lipid profile

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