Cytosine arabinoside (Cytarabine)

Details About Generic Salt ::  Cytosine arabinoside (Cytarabine) 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
CYTOSINE ARABINOSIDE (CYTARABINE)
ANTIMETABOLITE, PYRIMIDINE ANALOG | ANTI-NEOPLASTIC
PK: D: Extensive M: Hepatic E: Urine

Indications & Dose: ACUTE MYELOID LEUKEMIA Combination therapy IV Adult Induction: 100mg/m2/day or 100mg/m2/dose BID as continuous inf for 1wk | LEUKEMIC MENINGITIS IT Adult 10-30mg/m2 q2-4days | LYMPHOMATOUS MENINGITIS IT Adult 50mg q2wk for 5 doses, then q4wk for 5 doses

Contra: Hypersensitivity, active meningeal infect

Precautions: Renal/hepatic disease, active infect, decreased bone marrow reserve, other chronic illnesses

ADR: Serious: myelosuppression, blood disorders, hepatic dysfunction, thrombophlebitis, chest pain, pericarditis, Anal inflammation/ulceration, neural toxicity, neuritis, skin ulceration, urticaria, bowel necrosis, esophageal ulceration, pancreatitis, urinary retention, conjunctivitis, renal dysfunction, anaphylaxis, Others: dyspnea, Inj site cellulitis, abdominal pain, Fever, rash, alopecia, pruritus, anorexia, diarrhea, mucositis, nausea, vomiting, dizziness, headache

DDI: Serious Aciclovir (oral) bioavailability reduces by drug (high dose), Dipyridamole increases drug toxicity

Monitor: LFTs, CBC with differential & platelet count, SeCr, BUN, serum uric acid

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