Decitabine

Details About Generic Salt ::  Decitabine 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
DECITABINE
DNA METHYLATION INHIBITOR | ANTI-NEOPLASTIC
PK: D: 63-89 L/m2 M: Hepatic

Indications & Dose: MYELODYSPLASTIC SYNDROME IV Adult 15mg/m2 q8hrs for 3days cycle, cycle repeat for q6 wks for a min of 4 cycles. If hematological recovery is incomplete, increase cycle length to q10 wks and reduce dose to 11 mg/m2 q8hrs upon restarting therapy, maintain/increase dose with subsequent cycles

ADR: Serious: hyperglycemia, cardiorespiratory arrest, increased blood bilirubin, intracranial hemorrhage, abnormal LFTs, pulmonary edema, AF, central line infection, febrile neutropenia, myelosuppression, edema, tachycardia, depression, pharyngitis, Others: fatalities, fatigue, pyrexia, GI disturbances, petechiae, lethargy

Monitor: CBC with differential & platelets, liver enzymes, SeCr

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