Dinoprostone

Details About Generic Salt ::  Dinoprostone 

Main Medicine Class:: Reproductive System   Sub Medicine Class ::  Oxytocics

11C. OXYTOCICS in 11. REPRODUCTIVE SYSTEM
DINOPROSTONE
PROSTAGLANDIN (E2, PGE2) | ABORTIFACIENT, CERVICAL RIPENING AGENT
PK: M: Lungs, liver, kidney E: Urine, feces

Indications & Dose: ABORTION VAG Adult Insert 20mg (1 suppository) high in vagina, repeat at 3-5h intervals until abortion occurs, continuous use >2 days is not recommended | CERVICAL RIPENING FOR LABOR INDUCTION VAG Adult Apply 0.5mg (as gel) into the cervical canal, may repeat q6h if needed max 1.5mg/day. Vaginal insert: Place 1 insert (10mg) transversely into the posterior fornix of the vagina (to be removed at the onset of active labor/after 12h)

Contra: Hypersensitivity, predisposition to uterine rupture, history of pelvic inflammatory disease, active cardiac/pulmonary/renal/hepatic disease, myometrial route, vaginal preparations in induction of labour once the membranes are ruptured, placenta praevia, unexplained vaginal bleeding during pregnancy, major cephalopelvic disproportion/fetal malpresentation, history of caesarean section/major uterine surgery, untreated pelvic infect, fetal distress, grand multiparas & multiple pregnancy, history of difficult/traumatic delivery

Precautions: Glaucoma, raised IOP, history of asthma/epilepsy, CVD, history of hypertonic uterine contractility/tetanic uterine contractions, HTN, uterine scarring

ADR: Serious: severe uterine contractions, pulmonary/amniotic fluid embolism, abruptio placenta, fetal distress, maternal HTN, bronchospasm, rapid cervical dilation, cardiac arrest, uterine rupture, stillbirth/neonatal death, flushing, uterine hyper-contractility with/without fetal bradycardia, Others: low apgar scores, Nausea, vomiting, diarrhea, uterine hypertonus, shivering, headache, dizziness, temporary pyrexia, raised WBC count, erythema, fever, backache

Monitor: Gel, insert: Fetal HR, uterine activity, progression of cervical dilation & effacement; Suppository: Confirmation of fetal death