Diphenhydramine

Details About Generic Salt ::  Diphenhydramine 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

6C. ANTI-TUSSIVES/MUCOLYTICS/EXPECTORANTS in 6. RESPIRATORY SYSTEM
DIPHENHYDRAMINE
H1-ANTAGONIST | ANTI-TUSSIVE, ANTI-EMETIC, ANTI-ALLERGIC
also comes under 6B. Anti-Histamines and Nasal Decongestants in 6. Respiratory System,  
PK: A: Well absorbed D: Extensive, 3-22 L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: ALLERGIC REACTIONS PO Adult 25-50mg q6-8h Child 2-6 yr: 6.25mg q4-6h max 37.5mg/day, 6-12 yr: 12.5-25mg q4-6h max 150mg/day, >12 yr: 25-50mg q4-6h max 300mg/day | IV/IM Adult 10-50mg/dose or 100mg as single dose max 400mg/day Child 5mg/kg/day or 150mg/m2/day in divided doses q6-8h max 300mg/day | ANTITUSSIVE PO Adult 25mg q4h, max 150mg/day Child 2-<6 yr: 6.25mg q4h, max 37.5mg/day, 6-<12 yr: 12.5mg q4h, max 75mg/day, >12 yr: 25 mg q4h, max 150mg/day | MOTION SICKNESS PO Adult 25-50mg q6-8h Child 5mg/kg/day or 150mg/m2/day in divided doses q6-8h, max 300mg/day | IV/IM Adult 10-50mg/dose or 100mg as single dose max 400mg/day Child 5mg/kg/day or 150mg/m2/day in divided doses q6-8h max 300mg/day | PAIN & ITCHING TP Adult Apply 1% or 2% to affected area TID/QID Child >2 yr: Apply 1% or 2% to affected area TID/QID

Contra: Hypersensitivity, acute asthma, neonates/premature infant

Precautions: Severe hepatic disease, angle-closure glaucoma, seizure disorders, prostatic hypertrophy, CVD, hyperthyroidism, elderly, urinary retention, pyloroduodenal obstruction

ADR: Serious: tachycardia, blurred vision, urinary frequency/retention, hypotension, Others: palpitations, photosensitivity, decreased appetite, pain at IM Inj site, tinnitus, diarrhea, constipation, dry mouth, dysuria, Drowsiness, dizziness, headache, paradoxical stimulation

DDI: Serious Alcohol detrimental effects increases by drug, Metoprolol inhibits the metabolism of drug (more risk in patients with HF)

Diet: With/without food

Monitor: Cardiovascular status in patients with CVD, mental alertness

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