Dipyridamole

Details About Generic Salt ::  Dipyridamole 

Main Medicine Class:: Hematological System   Sub Medicine Class ::  Anti Platelets

5A. ANTI-PLATELETS in 5. HEMATOLOGICAL SYSTEM
DIPYRIDAMOLE
PLATELET ADHESION INHIBITOR | ANTI-PLATELET
PK: A: Variable D: 2-3 L/kg (Vd) M: Hepatic E: Feces

Indications & Dose: DIAGNOSTIC AGENT IN CORONARY ARTERY DISEASE IV Adult 0.14mg/kg/min for 4 min, max 60mg | THROMBOEMBOLISM Adjuvant therapy/Prophylactic therapy PO Adult 75-100mg QID along with warfarin cardiac valve replacement Child >12 yr: Same as adult dose

Contra: Hypersensitivity, arrhythmias, conduction disorders, asthma, history of bronchospasm

Precautions: Hepatic impairment, hypotension, unstable angina, aortic stenosis, recent MI, coagulation disorders, HF, other antiplatelets/anticoagulants

ADR: Serious: Cardiac arrhythmias, chest pain, hypersensitivity reactions, hypotension, Others: GI disturbances, nausea, vomiting, diarrhea, headache, dizziness, faintness, facial flushing, skin rash

DDI: Serious Digoxin absorption increased, Coumarins increases risk of serious bleeding, β-blockers leads to bradycardia & asystole, Adenosine levels increases, Lansoprazole/Antacids reduces drug bioavailability, Theophylline/Aminophylline reduces drug effects

Diet: 1h before food

Monitor: BP, HR, ECG

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