The Brand Name DOLOSAFE-D Has Generic Salt :: Tramadol
DOLOSAFE-D Is From Company Tidal Lab Priced :: Rs. 52.65
DOLOSAFE-D have Tramadol is comes under Sub class #N/A of Main Class #N/A
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
|Salt Name : OR Generic Name||Form||Price : MRP /Probable||Packing|
Indications for Drugs ::
Moderate to severe pain, Postoperative pain
Drug Dose ::
Adult: PO Moderate to severe pain 50-100 mg 4-6 hrly. Max: 400 mg/day. Extended-release 50-100 mg 1-2 times/day. Max: 300 mg/day. Renal impairment: CrCl (ml/min) <10 contraindicated. 10 to <30 increase dosing interval 12hrly. max: 200 mg>75 yr Increase dosing interval. Renal impairment: CrCl (ml/min) 10-30 Increase dosing interval to 12 hrly. <10 contraindicated. hepatic impairment: severe: increase dosing interval to 12 hrly. Contraindication ::
Suicidal patients, acute alcoholism; head injuries; raised intracranial pressure; severe renal impairment; lactation.
Drug Precautions ::
Hypothyroidism; adrenocortical insufficiency; renal or hepatic impairment; history of epilepsy or increased risk of seizures; inflammatory or obstructive bowel disease; myasthaenia gravis; respiratory depression; prostatic hyperplasia. Pregnancy.
Drug Side Effects ::
Sweating, dizziness, nausea, vomiting, dry mouth, fatigue, asthenia, somnolence, confusion, constipation, flushing, headache, vertigo, tachycardia, palpitations, miosis, insomnia, orthostatic hypotension, seizures, CNS stimulation e.g. hallucinations. Potentially Fatal: Respiratory depression.
Pregnancy category ::
Drug Mode of Action ::
Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It alters perception and response to pain by binding to mu-opiate receptors in the CNS.
Drug Interactions ::
Increased risk of convulsions or serotonin syndrome w/ SSRI, serotonin-norepinephrine reuptake inhibitors (SNRI), TCA and other seizure threshold lowering drugs (e.g. bupropion, mirtazapine, tetrahydrocannabinol). Decreased serum concentrations w/ carbamazepine. May potentiate the anti-depressant effect of norepinephrine, 5-HT agonists or lithium. Increased INR and ecchymoses w/ coumarin derivatives (e.g. warfarin). Potentially Fatal: Increased risk of seizure and serotonin syndrome w/ MAOIs.