Doripenem

Details About Generic Salt ::  Doripenem 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Other Beta Lactams

13D. OTHER BETA LACTAMS in 13. ANTI-INFECTIVES
DORIPENEM
CARBAPENEM | ANTI-INFECTIVE
PK: D: 16.8L(Vd) M: Non-CYP mediated E: Urine (70%) & feces (1%)

Indications & Dose: INTRA-ABDOMINAL INFECT Complicated/Severe IV Adult Inf: 500mg TID 5-14 days over 1h | PYELONEPHRITIS IV Adult Inf: 500mg TID 10-14 days over 1h | URINARY TRACT INFECT Complicated IV Adult Inf: 500mg TID 10-14 days over 1h

Contra: Hypersensitivity, anaphylactic reactions to ß-lactam antibiotics

Precautions: Avoid prolong therapy, renal impairment

ADR: Serious: phlebitis, renal impairment, SJS, TEN, anaphylaxis, Others: headache, nausea, diarrhea, oral candidiasis, anemia, pruritus

DDI: Serious Probenecid increases drug plasma level

Diet:

Monitor: Signs & symptoms of anaphylaxis, RFT, CBC

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