Doxazosin

Details About Generic Salt ::  Doxazosin 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Hypertensives

10C. DRUGS FOR PROSTATE DISORDERS in 10. GENITO-URINARY SYSTEM
DOXAZOSIN
SYMPATHOLYTIC, PERIPHERALLY ACTING ANTIADRENERGIC | ANTI-HYPERTENSIVE
also comes under 4D. Anti-Hypertensives in 4. Cardiovascular System,  
PK: A: Well absorbed M: Hepatic E: Feces, urine

Indications & Dose: BENIGN PROSTATIC HYPERPLASIA PO Adult IR: 4-8mg/day, max 8mg/day; ER: 4mg OD, titrate based on response & tolerability q3-4 wk, max 8mg/day | HYPERTENSION PO Adult 1mg OD, may be increases to 2mg, thereafter titrate upwards, max 16mg/day. If therapy is discontinued for several days, restart at 1mg & titrate as before

Contra: Hypersensitivity, HF

Precautions: Renal/hepatic impairment, angina, increased GI obstruction, elderly

ADR: Serious: Arrhythmias, orthostatic hypotension, hypotension, edema, palpitation, syncope, flushing, conjunctivitis, blurred vision, arthritis, myalgia, gout, Others: Dizziness, vertigo, headache, depression, drowsiness, fatigue, nervousness, weakness, rhinitis, pharyngitis, nausea, vomiting, diarrhea, flatulence, dry mouth, decreased libido, sexual dysfunction, dyspnea

DDI: Serious Diuretics/ACEIs results in an additive hypotensive effect, Tadalafil/Sildenafil/Vardenafil results in postural hypotension

Diet: With food

Monitor: BP, standing & sitting/supine, syncope

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