Doxycycline

Details About Generic Salt ::  Doxycycline 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Tetracyclines

13F. TETRACYCLINES in 13. ANTI-INFECTIVES
DOXYCYCLINE
TETRACYCLINES | ANTI-INFECTIVE
PK: A: Rapid/well absorbed D: Extensive M: Partially inactivated in GI tract by chelate formation E: Feces, urine

Indications & Dose: ANTHRAX Postexposure prophylaxis PO Adult 100mg BID 60 days Child <8 yr (<45 kg): 2.2mg/kg (up to 100 mg) BID 60 days, >8 yr (>45 kg): Same as adult dose | BRONCHITIS PO/IV Adult 100mg BID | BRUCELLOSIS Combination therapy PO Adult 100mg BID 6 wk with rifampin/streptomycin | CHLAMYDIAL INFECT Uncomplicated PO Adult 100mg BID 1 wk Child =>8 yr (>45 kg): Same as adult dose | CHOLERA PO General 300mg single dose | COMMUNITY-ACQUIRED PNEUMONIA PO/IV Adult 100mg BID | EPIDIDYMITIS Combination therapy PO Adult 100mg BID 10 days with ceftriaxone | GONOCOCCAL INFECTION Uncomplicated Combination therapy PO Adult 100mg BID 1 wk in combination with a cephalosporincervix, pharynx, rectum, urethra | GRANULOMA INGUINALE PO Adult 100mg BID 3 wkdonovanosis | INHALATIONAL/CUTANEOUS ANTHRAX IV Adult 100mg BID 60 days, once the condition is stable switch to oral therapy Child <45 kg: 2.2mg/kg (up to 100mg) BID 60 days, >45 kg: Same as adult dose | LATENT SYPHILIS PO Adult 100mg BID 4 wk Child 12–18 yr: Same as adult dose | LYME ARTHIRITIS PO Adult 100mg BID Child >8 yr: 4mg/kg/day in 2 divided doses, max 100mg/dose 28 days | LYME DISEASE PO Adult 100mg BID 10-21 days (early lyme disease without neurologic manifestations) Child >8 yr: 1-2mg BID 10-21 days, max 100mg/dose (early lyme disease without neurologic manifestations) | MALARIA Prophylactic therapy PO Adult 100mg/day 1-2 days prior to traveling to endemic area, continue daily during travel & for 4 wk after leaving endemic area Child >8 yr: 2mg/kg/day, max 100 mg/day 1-2 days prior to traveling to endemic area, continue daily during travel & for 4 wks after leaving endemic area | NON-GONOCOCCAL URETHRITIS PO Adult 100mg BID 1 wk Child 12–18 yr: 100mg BID 1 wk | PELVIC INFLAMMATORY DISEASE PO Child 12–18 yr: 100mg BID 2 wk | Combination therapy PO/IV Adult 100mg BID cefoxitin or cefotetan, | PLAGUE PO/IV Adult Initially 200mg, then 100mg BID or 200mg OD 10 days | PRIMARY/SECONDARY SYPHILIS PO Adult 100mg BID 2 wk Child 12–18 yr: Same as adult dose | PROCTITIS Combination therapy PO Adult 100mg BID 7 days with ceftriaxone | RICKETTSIAL INFECT PO/IV Adult 100mg BID 2-3 wk Child 2.2mg/kg BID | TULAREMIA IV Adult Initially 100mg BID 14-21 days Child <45 kg: 2.2mg/kg BID 14-21 days, >45 kg: 100mg BID 14-21 days

Contra: Hypersensitivity, SLE

Precautions: Myasthenia gravis, avoid direct exposure to sunlight/artificial UV light, myasthenia gravis, hepatic/renal impairment

ADR: Serious: Intracranial HTN, pericarditis, angioneurotic edema, erythema multiforme, exfoliative dermatitis, anaphylactoid purpura, anaphylaxis, bulging fontanels, serum sickness, SLE exacerbation, blood disorders, hepatotoxicity, pseudomembranous colitis, SJS, TEN, hypoglycemia, Others: diarrhea, dysphagia, enterocolitis, glossitis, inflammatory lesions in anogenital region, nausea, tooth discoloration, vomiting, Photosensitivity, rash, skin hyperpigmentation, brown/black discoloration of thyroid gland

DDI: Serious Ergotamine/Dihydroergotamine causes ergotism, Alcohol decreases serum drug levels, Coumarins increases the risk of over-coagulation, Rifampicin markedly reduces drug levels, Carbamazepine/Barbiturates/Phenytoin reduces serum drug level below MIC level, Antacids reduces therapeutic effectiveness of of drug

Diet: 1h before/2h after food

Monitor: CBC, LFTs, renal function test periodically with prolonged therapy