Entacapone

Details About Generic Salt ::  Entacapone 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM
ENTACAPONE
COMT INHIBITOR | ANTI-PARKINSONIAN
PK: A: rapid D: Vdss: 20L (IV) E: Feces (90%), Urine (10%)

Indications & Dose: PARKINSON’S DISEASE Adjunct therapy PO Adult 200mg with each dose of Levodopa/Carbidopa, max 1600mg/day; may reduce the dose of levodopa by 10-30% within the first few weeks of treatment

Contra: pheochromocytoma, history of NMS/nontraumatic rhabdomyolysis, hepatic impairment, hypersensitivity, concomitant use of nonselective MAOIs

Precautions: biliary obstruction, history of dyskinesia, patients at risk of hypotension, caution during driving/operating machinery;, avoid abrupt drug withdrawal

ADR: Serious: orthostatic hypotension, Others: diarrhea, abdominal pain, vomiting, dry mouth, flatulence, gastritis, hyperkinesia, back pain, anxiety, taste perversion, nausea, dyskinesia

DDI: Others Droperidol increases entacapone levels, CNS Depressants/Alcohol/MAOIs levels increases

Diet: Without food

Monitor: Signs & symptoms of parkinson’s disease, liver function test, BP, mental status, se iron

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