Epirubicin

Details About Generic Salt ::  Epirubicin 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
EPIRUBICIN
ANTHRACYCLINE | ANTI-NEOPLASTIC ANTIBIOTIC
PK: D: 21-27 L/kg (Vss) M: Hepatic E: Feces (34%-35%); urine (20%-27%)

Indications & Dose: BREAST CANCER Combination therapy/Adjuvant therapy IV Adult 60mg/m2 over 15-20min as inf on days 1 & 8 q28days for 6 cycles with cyclophosphamide & fluorouracil or 100mg/m2 over 15-20min on day 1 q21days for 6 cycles with cyclophosphamide & fluorouracil

Contra: Hypersensitivity, severe myocardial insufficiency, severe arrhythmias, recent MI, severe hepatic dysfunction, baseline neutrophil count <1500/mm3, previous treatment with anthracyclines up to maximum cumulative doses, patients with CVD

Precautions: Hepatic impairment, previous/recent radiation therapy

ADR: Serious: Blood disorders, severe cardiotoxicity, HF, conjunctivitis, Others: nausea, vomiting, diarrhea, mucositis, amenorrhea, alopecia, rash, pruritus, darkening of soles, palms & nails, anorexia, neutropenic fever, hot flashes, lethargy, stomatitis & oesophagitis

DDI: Serious Verapamil increases bone marrow depressant toxicity, Ciclosporin increases drug levels, Cimetidine increases exposure to drug, Granisetron potentiates cytotoxic effects of drug, Paclitaxel toxicity raises

Monitor: Inj site during infusion, CBC & platelet count, LFTs, SeCr, ECG & LVEF

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