Ergotamine

Details About Generic Salt ::  Ergotamine 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

1H. ANTI-MIGRAINE & ANTI- VERTIGO DRUGS in 1. NERVOUS SYSTEM
ERGOTAMINE
ERGOT ALKALOID | VASOCONSTRICTOR
PK: A: Poor D: Extensive M: Hepatic E: Feces

Indications & Dose: HEADACHE ATTACKS Prophylactic therapy PO/RECTAL Adult 1-2mg 1-2h before an expected attack during a cluster period or 1-2h before bedtime for nocturnal attacks, given 5-6 days/wk | MIGRAINE PO/SL Adult 1-2mg, repeat 30min later if needed, max 6mg/day, maintain min 4 day gap b/w successive 24h course (max 12mg/wk) & should receive no more than 2 courses/month | RECTAL Adult 2mg as suppositories, repeat after 1h if needed, max 4mg/day & 8mg/wk with min 4 day gap between successive 24h course | Inh Adult 360µg (one dose) inhale at onset of attack & repeat after 5min if needed, max 6 inhalation/day & 12 inhalation/wk, min 4 day gap between successive 24h course

Contra: Hypersensitivity, severe/uncontrolled HTN, shock, severe/persistent sepsis, PVD, IHD, temporal arteritis, hyperthyroidism, hepatic/renal impairment, basilar/hemiplegic migraine, CAD, obliterative vascular disease, Raynaud’s syndrome, acute porphyria

Precautions: Anemia, risk of peripheral vasospasm, elderly, dependence, CVD

ADR: Serious: ergotism, arrhythmias, MI, gangrene, heart-valve fibrosis, cerebral ischemia, seizures, extrapyramidal effects, blood disorders, blurred vision, Others: anxiety, hallucinations, urinary retention, thrombosis, sleep disturbances, tremor, constipation, dry mouth, Nausea, vomiting, abdominal pain, weakness, muscle pains, numbness & tingling of the fingers & toes, dizziness, cyanosis, peripheral vasoconstriction, paraesthesia

DDI: Serious HIV protease inhibitors/Azoles/Macrolides/Tetracyclines causes ergot toxicity, β-blockers leads to peripheral vasoconstriction & HTN

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