Details About Generic Salt ::  Erlotinib 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
ERLOTINIB
KINASE INHIBITOR | ANTI-NEOPLASTIC
PK: A: 60% (on empty stomach), 100% (full stomach) D: 94-232L M: Hepatic E: Feces, Urine

Indications & Dose: LOCALLY ADVANCED, UNRESECTABLE/METASTATIC PANCREATIC CANCER Combination therapy/First-line therapy PO Adult 100mg/day with gemcitabine | LOCALLY ADVANCED/METASTATIC NON-SMALL CELL LUNG CANCER Second-line therapy PO Adult 150mg/day

Precautions: pulmonary fibrosis, hepatic impairment, diarrhea, pneumonitis, interstitial pneumonia, obliterative bronchiolitis, concurrent warfarin therapy, children, respiratory distress syndrome

ADR: Others: fatigue, rash, pruritus, diarrhea, acne, abdominal pain, Pneumonitis, infect

DDI: Serious Ranitidine/Omeprazole decreases drug exposure, Rifampicin/Ketoconazole impairs drug metabolism, Ciprofloxacin increases drug exposure

Diet: 1h before or 2h after food

Monitor: LFTs, INR/PT, signs & symptoms of respiratory disorders, serum electrolytes

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