Eslicarbazepine

Details About Generic Salt ::  Eslicarbazepine 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Anti Epileptics

1C. ANTI-EPILEPTICS in 1. NERVOUS SYSTEM
ESLICARBAZEPINE
ANTI-EPILEPTIC

Indications & Dose: PARTIAL-ONSET SEIZURES Adjunct therapy PO Adult 400mg/day for 1wk, MD 800mg/day to max 1200mg/day(initiate after patient tolerate MD)Dose may vary among the brands

Contra: Hypersensitivity, severe hepatic impairment, concomitant use of CYP3A4 inducers

Precautions: Withdraw gradually, during driving/operating machinery

ADR: Serious: Blurred vision, peripheral edema, dysarthria, memory impairment, hypertension, tremor, balance disorder, visual impairment, hyponatremia, Others: Dizziness, somnolence, nausea/vomiting, headache, diplopia, fatigue, nystagmus, cough, ataxia, vertigo, diarrhea, asthenia, falls, depression, rash, constipation, abdominal pain, gait disturbance, UTI, insomnia, gastritis

DDI: Others Topiramate/Lamotrigine clearance increases, Carbamazepine clearance increases, decreases Eslicarbazepine levels, Phenytoin/Barbiturates decreases Eslicarbazepine levels, Cisapride/Astemizole/Clopidogrel/Ergotamine/Ethinyl estradiol/Lovastatin/Sildenafil/Sirolimus/Tolvaptan effect decreases and leads to serious/life threatening interaction, Oxcarbazepine either increases effects of other drug (pharmacodynamic synergism), Artemether/Abiraterone/Dienogest/Estradiol valerate/Lumefantrine/Paracetamol/Praziquantel/Roflumilast level decreases

Diet: With/without food

Monitor: Na levels, for breathing difficulties/swelling, for notable changes in behavior

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