Ezetimibe

Details About Generic Salt ::  Ezetimibe 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Fluid , Electrolyte Preparations

4F. ANTI-HYPERLIPIDEMICS in 4. CARDIOVASCULAR SYSTEM
EZETIMIBE
CHOLESTEROL ABSORPTION INHIBITOR | ANTI-HYPERLIPIDEMIC
PK: A: Rapid M: Small intestine & hepatic E: Feces, urine

Indications & Dose: HOMOZYGOUS SITOSTEROLEMIA PO Adult 10mg/day Child =>10 yr: Same as adult dose Elderly Same as adult dose | PRIMARY HYPERCHOLESTEROLEMIA PO Adult 10mg/day Child =>10 yr: Same as adult dose Elderly Same as adult dose

Contra: Hypersensitivity, concomitant use with an HMG-CoA reductase inhibitor, moderate-to-severe hepatic impairment, children <10yrs

Precautions: Mild hepatic impairment, severe renal impairment (Clcr <30 mL/min)

ADR: Serious: Angioedema, arthralgia, hepatitis, pancreatitis, myalgia, cholelithiasis, thrombocytopenia, Others: Headache, abdominal pain, diarrhea, GI disorders, hypersensitivity reactions, rash, fatigue, chest pain

DDI: Serious Rifampicin abolishes drug levels, Fenofibrate/Ciclosporin/Gemfibrozil increases drug levels, Colestyramine reduces drug exposure

Diet: With/without food

Monitor: Lipid profile, LFT & signs & symptoms of cholelithiasis

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