Famotidine

Details About Generic Salt ::  Famotidine 

Main Medicine Class:: Gastrointestinal System   Sub Medicine Class ::  GERD,

7A. GERD, ULCER/ANTACIDS in 7. GASTROINTESTINAL SYSTEM
FAMOTIDINE
H2-RECEPTOR ANTAGONIST | ANTI-ULCER
PK: A: Readily but incompletely absorbed D: Infants: 0-3 months: 1.4-1.8 L/kg; >3-12 months: 2.3 L/kg; Children: 2 L/kg; Adults: 1 L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: ESOPHAGITIS PO Adult 20/40mg BID 12 wk | GASTRIC ULCER PO Adult 40mg/day HS | GASTROESOPHAGEAL REFLUX DISEASE PO Adult 20mg BID 6 wk Child <3 months: 0.5mg/kg OD, 3-12 months: 0.5mg/kg BID, 1-16 yr: 1mg/kg/day in 2 divided doses, max 40mg BID | H.PYLORI INFECT PO Adult 40mg/day at HS for 4-8 wks, MD 20mg/day at HS | HYPERSECRETORY CONDITIONS PO Adult Initially 20mg q6h, may be increase in increments up to 160mg q6h | PEPTIC ULCER PO Adult Initially 20mg q6h, may be increase up to 160mg q6h Child 1-16 yr: 0.5mg/kg/day HS max 40mg/day | IV Child 1-16yr: 0.25mg/kg q12h, max 40mg/day

Contra: Hypersensitivity

Precautions: Moderate-to-severe renal impairment

ADR: Serious: Hypersensitivity reactions, Others: Headache, fatigue, dizziness, drowsiness, insomnia, pharyngitis, sinusitis, nausea, vomiting, diarrhea, constipation, abdominal pain, joint pain, pruritus, rash, fever, anorexia, gynecomastia, impotence

DDI: Serious Dipyridamole/Atazanavir absorption reduces, Cefpodoxime bioavailability reduces, Probenecid decreases drug renal clearance, Iron compounds/Interferons leads to irrelevant reduction in drug levels, Norfloxacin levels reduces, Azoles/Antacids reduces drug absorption

Diet: With/without food

Monitor: GI signs and symptoms, BUN and SeCr levels in renal impairment patients

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